Six essential genes located near the mouse albino locus have been identified as required during specific periods of development. Amongst these six, each is required either during the preimplantation stages of development, at specific times during gastrulation, within 12 hrs after birth or during juvenile development. These genes were identified as a result of extensive genetic complementation analysis using embryos homozygous for the albino deletions. Although, in principal, the associated developmental abnormalities could result from loss of multiple genes, the deletion (...) phenotype in one case is identical to that induced by chemical mutagenesis. These results indicate that the abnormalities observed in deletion homozygotes may result from single gene loss. The deletions have proven useful not only as genetic tools to localize the position of the genes, but also as molecular entry points to the regions containing these genes. The current methodology being used to isolate candidate genes from the albino region is also reviewed here. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Virtue of NonviolenceShyam RanganathanThe Virtue of Nonviolence. By Nicholas F. Gier. SUNY Series in Constructive Postmodern Thought. Albany: State University of New York Press, 2004. Pp. xv + 222. Hardcover $50.00.The Virtue of Nonviolence is Nicholas F. Gier's second book in the SUNY Series in Constructive Postmodern Thought, edited by the eminent Alfred North Whitehead scholar David Ray Griffin. It is a remarkable exercise in comparative philosophy (...) that attempts to come to terms with M. K. ("Mahatma") Gandhi's moral philosophy in light of the Chinese, European, and Indian traditions.According to Griffin, writing at the beginning of the present volume, Constructive Postmodernism, like the deconstructive, relativistic, and eliminative versions, takes a critical stand toward the modernist, Galilean-Cartesian-Baconian-Newtonian worldview and the associated ideal of a unitary (technologically supported) conception of human progress. Constructive Postmodernism departs from the alternative versions in its efforts to "overcome the modern worldview not by eliminating the possibility of worldviews (or 'metanarratives') as such, but by constructing a postmodern worldview through a revision of modern premises and traditional concepts in the light of inescapable presuppositions of our various modes of practice" (p. xiii). In the place of phenomenalism and the primary-secondary quality bifurcation of the modern period, constructive postmodernism embraces both non-sensory perception and organicism (p. xii). As a contributor to this series, Gier thus sets himself the project of explicating Gandhi's ethics as a species of Constructive Postmodernism.Gier opts to elaborate Gandhian, postmodern ethics in terms of early Buddhist thought (p. 3). This provocative option is motivated for Gier by his twin convictions, which he attempts to argue for throughout the book: (1) that a substance conception of self (characteristic of much Hindu and Jain thought) is not capable of explaining the moral cultivation and progress so essential to Gandhi's program (p. 6), and (2) the "Vedāntist philosophy, particularly the Advaita Vedānta with which Gandhi is usually associated, cannot support [an] action-context" ethics that emphasizes the dynamic importance of both theory and the facts on the ground—a program captured by Gandhi's idea of satyagraha (p. 3).Having stated the parameters of his project in his "Introduction," Gier in his first chapter, "Gandhi as a Postmodern Thinker," argues that "[a]lthough some evidence of a deconstructive postmodernism may be discerned, Gandhi is best allied with the constructive school of postmodernism" (p. 27). Of special interest in evaluating this book is Gier's observation that "if Gandhi is a postmodern thinker, Gandhi stands with Rāmānuja and Whitehead and not with Śaṅkara and Derrida," for Gandhi evokes models of organism absent in the thought of the latter two (p. 25)—an observation I shall return to later.In the second chapter Gier examines the Jain and "Hindu" view of ahiṁsā. Gier correctly notes the uncompromising, unpragmatic conception of ahiṁsā operative in Jain thought, which finds its highest realization in renunciation and not worldly [End Page 115] action—a position that Gier rightly contrasts with Gandhi's politically charged conception of ahiṁsā. This allows Gier to claim that the influence of Jainism on Gandhi's thought is "not as great as he or others have claimed" (p. 31). In contrast, Gier summarizes what he takes to be the "Hindu" view of ahiṁsā, based mainly on the Upaniṣads and Manu's Dharmaśāstra, which he supplements with an examination of the Bhagavad Gītā. Gier argues that from the Gītā Gandhi derives the "philosophy of active nonattachment" embodied in the doctrine of karma yoga. In the Hindu view, according to Gier, ahiṁsā is "relativized"—that is, its nature and scope are defined relative to social and ritual contexts and self-interest (e.g., ritual slaughter is an occasion when the general prohibition against killing is suspended in the context of "Hindu" ethics). However, Gandhi's conception of ahiṁsā is not relativized. Since it cannot be subsumed under a Jain conception, Gier suggests that we must look elsewhere—specifically to a Buddhist pragmatic ethics that would justify Gandhi's political conception, which allowed for the compromise of ahiṁsā for... (shrink)

Yoga-Sutras of Patanjali is a foundational psychological text that organizes, codifies, and systematically presents in s_tra form the psychology as practised in India around second century BCE. Its theme is to help humans free themselves from their congenital bondage due to conditioned existence and consequent suffering. The goal is to restore the person to her inherent unconditioned blissful being. The quintessence of Yoga is meditation. Meditation consists of dharana and dhyana, a contemplative state of passive attention precipitated by a prolonged (...) practice of concentration. Dhy_na practice leads to sam_dhi, a stand-still altered state in which the mind is controlled and restrained from habitual cognitive processing. This paper provides a theoretical background of Patanjali Yoga and a select review of empirical research on the neurophysiological correlates of meditation, highlighting on the one hand some of its methodological shortcomings and conceptual problems and suggesting on the other hand the areas of promise for further research on meditation. (shrink)

A review of empirical and theoretical work on reasoning and linguistic inference, which will be a useful introduction to the subject for students of language and thought. The book focuses on the relationship between what people do and what people are supposed to do when making inferences.

Modal ontolojik argüman, Tanrı’nın varlığını sadece bilfiil gerçek olan bu dünyada değil, bütün mümkün dünyalarda göstermeye yönelik bir argümandır. Anselm’in (1033-1109) Proslogion adlı eserinin 3. bölümünde “kendisinden daha büyüğü düşünülemeyen” şeklinde tanımlanan; Tanrı’nın var olmamasının da düşünülemeyeceğini, bu yüzden de varolmamasının imkansızlığı üzerinde kurulu yeni bir argüman bulunduğunu öne süren bazı araştırmacılar, bu argümanı mümkün dünyalar semantiği yardımıyla formüle edip, “modal ontolojik argüman” şeklinde adlandırmışlardır. Çok farklı şekillerde formüle edilmiş bu argüman kabaca Tanrı’nın mümkünse zorunlu olması, dolayısıyla bilfiil gerçek olan (...) bu dünyada da var olması gerektiğini savunur. (shrink)

Open peer commentary on the article “Designing Constructionist E-Books: New Mediations for Creative Mathematical Thinking?” by Chronis Kynigos. Upshot: Chronis Kynigos’s article invites us to explore how to make familiar objects for learning — namely, books — more constructionist. In my response, I ask questions about the affordances and potential limitations of books as central objects, particularly about the role of the learner in relation to the objects.

Un révolutionnaire sommeille en chaque Français, prêt hier comme aujourd'hui à briser les rentes et les privilèges. Dans le même temps, un expert l'observe et le dirige, planifiant autoritairement la société. Et un geek lui tape sur l'épaule, l'entraînant dans le monde inconnu des nouvelles technologies qui fourmille de promesses et de menaces. Ces trois influences parfois contradictoires nous font tourner la tête. Gaspard Koenig propose donc de les interpréter à la lumière d'une nouvelle philosophie politique, fondée sur l'autonomie individuelle. (...) Car ce dont la France a besoin, ce n'est pas d'un énième diagnostic économique, mais de principes solides dont on pourra déduire des réformes radicales. Revenons au modèle révolutionnaire, ce «jacobinisme libéral» incarné par le député du tiers état Isaac Le Chapelier. Rejetons la tentation planiste, léguée par le régime de Vichy et responsable encore aujourd'hui de tant d'injustice et d'exclusion. Apprenons à maîtriser l'utopie numérique, en imaginant un nouvel humanisme qui réponde aux défis de la Silicon Valley et un Etat 2.0 qui nous redonne le contrôle de notre destin numérique. Pays des libertés, la France meurt de servitude volontaire. Terminons, enfin, notre Révolution! Et chacun deviendra son propre maître. (shrink)

The norms and values of Post-Normal Science (PNS) are instrumental in guiding science advice practices. In this article, we report work in progress to systematically investigate the norms and values of PNS through a structured review. An archive of 397 documents was collected, including documents that contribute to the endeavour of ameliorating science advice practices from a PNS perspective. Action and structure-oriented viewpoints are used as complementing perspectives in the analysis of the ethos of PNS. From the action-perspective we study (...) how prototypes of norms and values are reflected upon in negotiations of normative issues relating to science advice. From the structural perspective we study how interrelated prototypes of norms and values are presupposed in prescriptions, proscriptions, and goals for science advice practices. Through this analysis we identify a plurality of interrelated prototypes of norms and values. Finally, we propose an acronym that integrates the analysed plurality of norms and values. As a mnemonic and communicative devise we call this ethos TRUST (Transparency, Robustness, Uncertainty management, Sustainability, and Transdisciplinarity) and propose TRUST as a nexus for future reflective negotiations of ambivalences in post-normal practices of science advice. (shrink)